This is the sequel to Rob Zombie's House of 1000 Corpses, set some time after the original films plot line it opens with a raid on the murderous Firefly home by Ruggsville County Sheriff John Wydell, brother of Firefly victim Deputy George Wydell (from the first film). After a shootout in which several deputies are killed , with one son killed, Mother Firefly is captured , Baby,and Otis escape and rendezvous later with the Firefly patriarch, the mad clown Capt Spaulding. After a mind blowing murder escapade at a dusty desert motel they retreat to a frontier town whorehouse run by Spaulding's adopted "brother" Charlie, while Sheriff Wydell slowly loses his mind in his quest for revenge. He enlists the help of two equally disgusting bounty hunters and tracks the the trio, now dubbed the "Devil'Rejects" by the media to their location and sets the stage for the final showdown.

The Devil's Rejects was financially successful, recouping its roughly $7 million budget during its opening weekend, and going on to earn over $16 million.
Despite the film's gruesome violence, prominent critic Roger Ebert offered a positive review, giving the film three out of a possible four stars. He considered The Devil's Rejects an improvement over its predecessor, and wrote, "There is actually some good writing and acting going on here, if you can step back from the material enough to see it."
In his review for the 2006 remake of The Hills Have Eyes, he once again made reference to Rejects. "I received some appalled feedback when I praised Rob Zombie's 'The Devil's Rejects', but I admired two things about it: (1) It desired to entertain and not merely to sicken, and (2) its depraved killers were individuals with personalities, histories and motives."